Functional Importance of Platelet-derived Growth Factor (PDGF) Receptor Extracellular Immunoglobulin-like Domains
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منابع مشابه
Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure.
Platelet-derived growth factor (PDGF)-C is a novel member of the PDGF family that binds to PDGF alphaalpha and alphabeta receptors. The growth factor domain of PDGF-C (GFD-PDGF-C) was expressed in high yields in Escherichia coli and was purified and refolded from inclusion bodies obtaining a biologically active growth factor with dimeric structure. The GFD-PDGF-C contains 12 cysteine residues, ...
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A label-free aptasensor for platelet-derived growth factor (PDGF) protein is reported. The aptasensor uses mixed self-assembled monolayers (SAMs) composed of a thiol-modified PDGF binding aptamer and 6-mercaptohexanol (MCH) on a gold electrode. The SAMs were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV) before an...
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Autocrine stimulation by platelet-derived growth factor-B (PDGF-B) like factors hasbeenwidely Implicated asan important mechanismin the causeand/or maintenanceof a variety of human tumors. However,normal human cells appear to be resistant to transformation by PDGF-B-like molecules,and a direct demonstrationof the tumor-promoting or tumor maintaining property of a PDGF-B autocrine system is lack...
متن کاملPlatelet - derived growth factor ( PDGF ) - AB - mediated phosphorylation of PDGF , 1 receptors Steven
Platelet-derived growth factor (PDGF) is a potent mitogen for cells of mesenchymal origin, and stimulates the proliferation of density-arrested Balb/c-3T3 fibroblasts (Pledger et al., 1978; Williams et al., 1982; Sturani et al., 1989; Coats et al., 1991). PDGF was first purified from human platelets and shown to consist of a heterodimer composed of two disulphide-linked polypeptide chains, desi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.52.33037